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Invitrogen™ ALKBH8 Polyclonal Antibody
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Catalog No. PA549590
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400 μL
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PA549590 400 μL
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Catalog No. PA549590 Supplier Invitrogen™ Supplier No. PA549590
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Description

Rabbit Polyclonal Antibody

ALKBH8 Polyclonal Antibody for Western Blot, IHC (P), Flow

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALKBH8
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.9 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene ALKBH8
Gene Accession No. Q96BT7
Gene Alias 4930562C03Rik; 8030431D03Rik; 9430088N01Rik; ABH8; alkB homolog 8, tRNA methyltransferase; AlkB homologue 8; alkB, alkylation repair homolog 8; alkB, alkylation repair homolog 8 (E. coli); Alkbh8; Alkylated DNA repair protein alkB homolog 8; LOW QUALITY PROTEIN: alkylated DNA repair protein alkB homolog 8; probable alpha-ketoglutarate-dependent dioxygenase ABH8; RGD1304687; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; TRM9; TRMT9; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; tRNA methyltransferase 9 homolog
Gene Symbols ALKBH8
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 494-523 amino acids from the C-terminal region of human ALKBH8.
Purification Method Ammonium sulfate precipitation
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91801
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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