alpha-1-Anti-Trypsin Polyclonal Antibody, Biotin, Rockland™

Goat Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-0392	Rockland Immunochemicals 2001061470100	100 μg
50-199-0393	Rockland Immunochemicals 200106147S	25 μL

Description

Store vial at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-Alpha-1-Anti-Trypsin is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Biotin, anti-Goat Serum as well as purified and partially purified a-1-anti-Trypsin [Human Plasma]. Cross reactivity against a-1-anti-Trypsin from other sources is unknown.

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Specifications

• Antigen: alpha-1-Anti-Trypsin
• Applications: ELISA, Immunoprecipitation, Western Blot
• Conjugate: Biotin
• Host Species: Goat
• Target Species: Human
• Gene Accession No.: P01009
• Gene ID (Entrez): 5265
• Immunogen: a1-Anti-Trypsin [Human Plasma]
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Gene: SERPINA1

• Concentration: 1 mg/mL
• Classification: Polyclonal
• Form: Lyophilized
• Regulatory Status: RUO
• Formulation: 0.02M potassium phosphate with 0.15M NaCl, 10 mg/mL BSA and 0.01% sodium azide; pH 7.2
• Gene Alias: a-1 AT; A1A; a1-antitrypsin; A1AT; AAT; Aat2; Aat-2; alpha-1 antitrypsin; Alpha-1 protease inhibitor; Alpha-1 protease inhibitor 1; Alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (protease inhibitor); Alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; alpha-1-antitrypsin null; alpha1AT; alpha-1-protease inhibitor; Alpha-1-proteinase inhibitor; Digestive Zymogen; Dom1; MGC23330; MGC9222; PI; PI1; PRO0684; PRO2209; PRO2275; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; Protease Serine 1; serine (or cysteine) peptidase inhibitor, clade A, member 1A; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1a; Serine Protease 1; Serine protease inhibitor 1-1; Serine protease inhibitor A1a; serine protease inhibitor alpha 1; Serpin A1; Serpin A1a; serpin family A member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; SERPINA1; Serpina1a; Short peptide from AAT; SPAAT; Spi1; Spi1-1; Spi1-3; TRP1; TRY1
• Gene Symbols: SERPINA1
• Primary or Secondary: Primary
• Product Type: Antibody