Invitrogen™ alpha-2b Adrenergic Receptor Monoclonal Antibody (5G10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA112721

Catalog No. 01-674-051

Description

A suggested positive control for this product is MDCK cells transfected with rat alpha2B adrenergic receptors.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.

Specifications

• Antigen: alpha-2b Adrenergic Receptor
• Classification: Monoclonal
• Concentration: 0.8 mg/mL
• Formulation: PBS with 0.08% sodium azide
• Gene Accession No.: P19328, P30545
• Gene Symbols: ADRA2B
• Immunogen: Synthetic peptide corresponding to the third intracellular loop of rat alpha 2b adrenergic receptor.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot, Immunocytochemistry
• Clone: 5G10
• Conjugate: Unconjugated
• Gene: ADRA2B
• Gene Alias: [a]2B; ADA2B; Adra2b; Adra-2b; ADRA2B adrenergic, alpha-2B-, receptor; ADRA2L1; ADRA2RL1; ADRARL1; Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; Adrenergic, alpha2B-, receptor class III; adrenoceptor alpha 2B; alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha2B; alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; alpha-2B adrenoreceptor; ALPHA2BAR; alpha-2BAR; alpha2-C2; FAME2; G-protein coupled receptor; subtype alpha2-C2
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 11552, 24174
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid