Invitrogen™ alpha Actinin 2 Recombinant Rabbit Monoclonal Antibody (7H1L69)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ 701914

Catalog No. PI701914

Description

This antibody is predicted to react with Monkey, Pig, Rat, Mouse Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

Specifications

• Antigen: alpha Actinin 2
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P35609, Q9JI91
• Gene Symbols: Actn2
• Immunogen: Peptides corresponding to human Sarcomeric alpha actinin/alpha actinin 2 [1) aa834-aa852, 2) aa5-aa24].
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Clone: 7H1L69
• Conjugate: Unconjugated
• Gene: Actn2
• Gene Alias: 1110008F24Rik; actinin alpha 2; actinin, alpha 2; ACTN2; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin-2; CMD1AA; CMH23; F-actin cross-linking protein
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 11472, 291245, 88
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Green Features: Responsibly packaged