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Invitrogen™ alpha/beta Tubulin Monoclonal Antibody (TU-10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119400

Catalog No. 01-676-148


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Description

Description

This antibody recognizes alpha, beta-tubulin heterodimer, a basic intracellular structural unit of microtubules. Alpha- and beta-tubulins form approximately 100 kDa tubulin heterodimer, a globular protein that polymerizes to form microtubules. Western Blot: Reducing conditions.

Tubulin protein is the major constituent of microtubules. Tubulin is a dimer of alpha and beta chains, which binds two molecules of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. There are at least six isotypes of both alpha- and beta- tubulin in human cells, which are distinguished by slightly different amino acid sequences and encoded by a large, multigene family that has been highly conserved throughout evolution. Although the most important functions of microtubules in proliferative cells are through their actions as components of the mitotic spindle, they are also involved in many other essential functions throughout the cell cycle of both malignant and nonmalignant cells. Anti-microtubule agents including Vinca alkaloids and taxanes may disrupt many of these essential functions.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

alpha/beta Tubulin
Monoclonal
1 mg/mL
TBS with 15mM sodium azide; pH 8
A2AQ07, P02550, P07437, P68369, P68370, Q71U36, Q767L7, Q9H4B7
TUBA1A, TUBB, TUBB1
Microtubule proteins from porcine brain.
100 μg
Primary
Human, Mouse, Rat, Pig, Multi-species
Antibody
IgM
Flow Cytometry, Western Blot, Immunocytochemistry
TU-10
Unconjugated
TUBB
2810484G07Rik; Alpha-tubulin 1; Alpha-tubulin 3; Alpha-tubulin isotype M-alpha-1; B-ALPHA-1; beta 5-tubulin; beta Ib tubulin; CDCBM6; CSCSC1; Detyrosinated tubulin alpha-1A chain; FLJ30169; H2 ALPHA; hum-a-tub1; hum-a-tub2; LIS3; M(beta)1; M40; OK/SW-cl.56; Talpha1 alpha-tubulin; Tuba1; Tuba-1; TUBA1A; TUBA3; TUBB; TUBB1; TUBB2A; TUBB5; Tubulin alpha; tubulin alpha 1a; tubulin alpha 3; tubulin alpha-1 chain; Tubulin alpha-1A chain; tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin beta; tubulin beta 1 class VI; tubulin beta chain; tubulin beta class I; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, alpha 1; tubulin, alpha 1A; tubulin, alpha, brain-specific; tubulin, beta 1 class VI; tubulin, beta 2A class IIa; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; a/ß-tubulin
Mouse
Purified
RUO
100134983, 100135051, 203068, 22142, 545486, 64158, 679312, 733686, 7846, 81027
4°C, do not freeze
Liquid
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