Invitrogen™ alpha Dystroglycan Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528179

Catalog No. PIPA528179

Description

Recommended positive controls: U87-MG, U87-MG membrane fraction extract. Predicted reactivity: Mouse (92%), Rat (92%), Dog (92%), Cat (95%), Rabbit (94%), Rhesus Monkey (98%), Bovine (93%).

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

Specifications

• Antigen: alpha Dystroglycan
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAG1
• Gene Alias: 156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100053150, 13138, 1605
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.28 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q14118, Q62165
• Gene Symbols: DAG1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 471 and 752 of Human alpha Dystroglycan.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Horse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov