Invitrogen™ alpha Internexin Recombinant Rabbit Monoclonal Antibody (5E5Z3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538082

Catalog No. PIMA538082

Description

Positive Samples: U-87MG, Mouse brain, Rat brain Immunogen sequence: EVAGYQDSIG QLENDLRNTK SEMARHLREY QDLLNVKMAL DIEIAAYRKL LEGEETRFST SGLSISGLNP LPNPSYLLPP RILSATTSKV SSTGLSLKKE E.

alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.

Specifications

• Antigen: alpha Internexin
• Classification: Recombinant Monoclonal
• Concentration: 0.13 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P23565, P46660, Q16352
• Gene Symbols: INA
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human Alpha Internexin (Q16352).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 5E5Z3
• Conjugate: Unconjugated
• Gene: INA
• Gene Alias: 66 kDa neurofilament protein; Alpha-internexin; alpha-Inx; AV028420; FLJ18662; FLJ57501; Ina; Inexa; internexin neuronal intermediate filament protein alpha; internexin neuronal intermediate filament protein, alpha; internexin, alpha; Intlaa; LOW QUALITY PROTEIN: alpha-internexin; MGC12702; NEF5; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; Nf66; NF-66; TXBP-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 226180, 24503, 9118
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov