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Invitrogen™ alpha Synuclein Monoclonal Antibody (Syn 211)
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Catalog No. PIMA512272
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500 μL
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Catalog No. Quantity
PIMA512272 500 μL
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Catalog No. PIMA512272 Supplier Invitrogen™ Supplier No. MA512272
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Description

Mouse Monoclonal Antibody

MA5-12272 targets Synuclein in IHC (P), ICC/IF, IP, and WB applications and shows reactivity with Human and Rat samples. The MA5-12272 immunogen is human recombinant alpha-synuclein.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha Synuclein
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone Syn 211
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene SNCA
Gene Accession No. P37377, P37840
Gene Alias Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
Gene Symbols SNCA
Host Species Mouse
Immunogen Human recombinant alpha-synuclein.
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29219, 6622
Target Species Human, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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