Invitrogen™ alpha Synuclein Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585791

Catalog No. PIPA585791

Description

Keep as concentrated solution. Predicted reactivity: Pig (100%), Sheep (100%), Chimpanzee (100%), Bovine (100%). Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS, mouse brain, rat brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Specifications

• Antigen: alpha Synuclein
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNCA
• Gene Alias: Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20617, 29219, 6622
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7
• Gene Accession No.: O55042, P37377, P37840
• Gene Symbols: SNCA
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human alpha Synuclein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG