ALPL Mouse anti-Human, Clone: OTI3A1, liquid, TrueMAB™

Catalog No.	Quantity
50-168-2577	100 μL

Catalog No. 50-168-2577 Supplier OriGene Supplier No. TA809117

Description

Mouse Monoclonal Antibody

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Specifications

• Antigen: ALPL
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI3A1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ALPL
• Gene Accession No.: P05186
• Gene Alias: AP-TNAP, APTNAP, HOPS, TNAP, TNSALP
• Gene Symbols: ALPL
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human ALPL produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 249
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1