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ALX3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 223581AP150UL

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Catalog No. 50-173-3847


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Description

Description

Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predomitly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predomit ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2′-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.
Specifications

Specifications

ALX3
Polyclonal
Unconjugated
ALX3
ALX homeobox 3, ALX3
Rabbit
Antigen Affinity Chromatography
RUO
11694, 257
-20°C
Liquid
Western Blot
0.27 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O70137, O95076
Alx3
ALX3 Fusion Protein Ag17937
150 μL
Primary
Human, Mouse
Antibody
IgG
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