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ALX3 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501733847 Shop All Proteintech Group Inc Products
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50-173-3847 150 μL
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Catalog No. 50-173-3847 Supplier Proteintech Group Inc Supplier No. 223581AP150UL
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Description

Rabbit Polyclonal Antibody

Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predomitly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predomit ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2′-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.

Specifications

Antigen ALX3
Applications Western Blot
Classification Polyclonal
Concentration 0.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ALX3
Gene Accession No. O70137, O95076
Gene Alias ALX homeobox 3, ALX3
Gene Symbols Alx3
Host Species Rabbit
Immunogen ALX3 Fusion Protein Ag17937
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11694, 257
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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