Cayman Chemical AlylescalInhydrochlorIde 10mg

Supplier:  Cayman Chemical 900198210 MG

An inhibitor of NOX1 NOX2 and NOX4 (Kis 1.08 0.57 and 0.63 UM respectively for the human enzymes) selective for these enzymes over xanthine oxidase and glucose oxidase (Kis >100 UM for both) prevents RANKL-induced increases in ROS levels in primary mouse BMDMs at 10 or 20 UM inhibits GM-CSF- and RANKL-induced primary mouse osteoclast differentiation at 1.1 3.3 or 10 UM increases femur bone mass density and strength and reduces femur and tibia resorption areas in OVX mice at 10 mg/kg per day reduces plasma and urinary levels of 8-isoprostane plasma levels of insulin triglycerides HDL LDL and creatinine urinary levels of albumin as well as renal fibrosis in a db/db mouse model of diabetic nephropathy at 60 mg/kg per day

Catalog No. 50-289-4904