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Apexbio Technology LLC AZD1480 935666-88-9 10mg
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Supplier:  Apexbio Technology LLC A413710

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AZD1480 (CAS 935666-88-9) is a small molecule inhibitor targeting Janus kinase (JAK) showing selectivity for JAK2 over JAK3 and modest selectivity over JAK1 at physiological ATP concentrations By suppressing phosphorylation-mediated activation of JAK2 AZD1480 subsequently inhibits downstream STAT3 and FGFR3 signaling pathways involved in tumor cell proliferation angiogenesis and metastasis Preclinical studies demonstrate its capability to reduce cellular growth and induce apoptosis in multiple myeloma cell lines (e g RPMI 8226 OPM-2 NCI-H929 Kms 18) primary myeloma samples and mouse xenograft tumor models AZD1480 serves as a probe in research investigating JAK-STAT signal transduction and cancer biology

Catalog No. 50-000-62564


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