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Amiodarone hydrochloride, Tocris Bioscience™

Catalog No. 409550
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50 mg
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Catalog No. Quantity
40-955-0 50 mg
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Catalog No. 40-955-0 Supplier R&D Systems Supplier No. 4095/50
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Description

Broad spectrum ion channel blocker; antiarrhythmic

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

Chemical Identifiers

CAS 19774-82-4
Molecular Formula C25H30ClI2NO3
Molecular Weight (g/mol) 681.778
InChI Key ITPDYQOUSLNIHG-UHFFFAOYSA-N
Synonym amiodarone hydrochloride, amiodarone hcl, amiodar, nexterone, pacerone, amiodaronum hydrochloride, ritmocardyl, rythmarone, angoron
PubChem CID 441325
IUPAC Name (2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone;hydrochloride
SMILES CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl

Specifications

Quantity 50 mg
Formula Weight 681.77
Percent Purity >99%
Chemical Name or Material Amiodarone hydrochloride

Safety and Handling

Recommended Storage Store at +4°C
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