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Apexbio Technology LLC CNX-774 1202759-32-7 5mg
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Supplier:  Apexbio Technology LLC B14085

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CNX-774 (CAS 1202759-32-7) is an orally bioavailable covalent and selective inhibitor of Bruton s tyrosine kinase (BTK) It forms an irreversible bond with the cysteine 481 residue in the ATP binding site of BTK In biochemical assays CNX-774 inhibits BTK activity with an IC below 1 nM in cellular assays inhibition occurs at 1 10 nM BTK plays a critical role in B cell receptor (BCR) signaling and mast cell activation processes central to B cell maturation and function CNX-774 is utilized as a tool compound in studies of B cell signaling autoimmune disease and related immune pathway research

Catalog No. 50-000-91196


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