AMPK alpha 1 Rabbit anti-Bovine, Human, Rat, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Bethyl Laboratories, Inc A300507AT
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval is not recommended. Based on 100% sequence identity, this antibody is predicted to react with Mouse and OrangutanAMPKa belongs to the family of AMP activated protein kinases, that plays a central role in regulating cellular and organismal energy balance in response to the balance between AMP/ATP, and intracellular Ca2+ levels. AMPK exists as a heterotrimer comprising of catalytic alpha subunit, and regulatory beta and gamma subunits. The alpha subunit is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses, and can mediate the effects of the adipokines leptin and adiponectin. Two isoforms differ in subcellular localization and AMP-dependence. Phosphorylation of threonine 172 in the alpha subunit is a key determit of AMPK activity.
|AMPK alpha 1|
|Between 350 and 400|
|Antigen affinity chromatography|
|Bovine, Human, Rat|
|Immunohistochemistry, Western Blot|
|TBS with 0.1% BSA and 0.09% sodium azide|
|AMPK, AMPKa1, MGC33776, MGC57364|
|540404, 5562, 65248|
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