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AMPK alpha 2 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Catalog No. 501557785
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50-155-7785 100 μL
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Catalog No. 50-155-7785 Supplier Bethyl Laboratories, Inc Supplier No. A300508A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Pig and Orangutan

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Specifications

Antigen AMPK alpha 2
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene PRKAA2
Gene Accession No. P54646, Q8BRK8
Gene Alias 5′-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK alpha-2 chain
Gene Symbols PRKAA2
Host Species Rabbit
Immunogen Between 350 and 400
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108079, 5563
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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