AMPK beta 2 Mouse anti-Human, Mouse, Rat, Clone: 2D5C1, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 665791IG150UL

Catalog No. 50-173-6997

Description

AMPK Beta 2 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

Specifications

• Antigen: AMPK beta 2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: O43741, Q6PAM0, Q9QZH4
• Gene Symbols: PRKAB2
• Immunogen: AMPK beta 2 Fusion Protein Ag5806
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: 2D5C1
• Conjugate: Unconjugated
• Gene: PRKAB2
• Gene Alias: AMPK subunit beta 2, PRKAB2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 108097, 5565, 64562
• Content And Storage: -20°C
• Form: Liquid