Invitrogen™ AMPK gamma-2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522331

Catalog No. PIPA522331

Description

Recommended positive controls: HepG2, Mouse brain. Predicted reactivity: Mouse (98%), Rat (97%), Chicken (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Specifications

• Antigen: AMPK gamma-2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKAG2
• Gene Alias: 2410051C13Rik; 5'-AMP-activated protein kinase subunit gamma-2; 5-AMP-activated protein kinase, gamma-2 subunit; AAKG; AAKG2; adenosine monophosphate-activated protein kinase gamma 2-subunit; AI854673; AMP-activated protein kinase gamma2 subunit; ampk gamma; AMPK gamma 2; AMPK gamma2; AMPK gamma-2 chain; AMPK subunit gamma-2; CMH6; H91620p; OTTHUMP00000211956; PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; WPWS
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108099, 51422
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.96 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q91WG5, Q9UGJ0
• Gene Symbols: PRKAG2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 386 and 569 of AMPK gamma 2 (Uniprot ID#Q9UGJ0).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov