Invitrogen™ Amylin Polyclonal Antibody

Catalog No.	Quantity
01-673-054	1 mL
PIPA532261	500 μL

Catalog No. 01-673-054 Supplier Invitrogen™ Supplier No. PA137075

Description

Rabbit Polyclonal Antibody

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is pancreas tissue.

Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

Specifications

• Antigen: Amylin
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA and 0.1% sodium azide; pH 7.6
• Gene: IAPP
• Gene Accession No.: P10997
• Gene Alias: Amylin; amylin peptide; DAP; Diabetes-associated peptide; IAP; Iapp; Insulinoma amyloid peptide; islet amyloid polypeptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); Rabbit Anti-Amylin
• Gene Symbols: IAPP
• Host Species: Rabbit
• Immunogen: Synthetic peptide derived from N-terminus of human amylin peptide.
• Purification Method: Antigen affinity chromatography
• Quantity: 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3375
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG