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Invitrogen™ Androgen Receptor (ARv7 Splice Variant) Recombinant Rabbit Monoclonal Antibody (HL1240)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA546971

Catalog No. PIMA546971


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Description

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial.

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017].
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Androgen Receptor (ARv7 Splice Variant)
Recombinant Monoclonal
1 mg/mL
PBS with no preservative
P10275
AR
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Androgen Receptor (ARv7 Splice Variant). The exact sequence is proprietary.
100 μL
Primary
Human
Antibody
IgG
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
HL1240
Unconjugated
AR
AIS; androgen receptor; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM
Rabbit
Protein A
RUO
367
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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