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Tocris Bioscience™ Angiopep-2-Cys

Catalog No. 89025
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Catalog No.
89-025 5 mg
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Catalog No. 89-025 Supplier Tocris Bioscience™ Supplier No. 8902/5
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Description

Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Angiopep-2-Cys is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present on brain endothelial cells and neurons. Angiopep-2-Cys is a conjugate of Angiopep-2 (Cat. No. 8828) and Cystein, and can be used to functionalize LNPs via thiol-maleimide click chemistry to target LRP1 receptors present on blood-brain barrier (BBB). mRNA LNPs functionalized with Angiopep-2-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.

Specifications

Purity 95%
CAS 906480-09-9
Content And Storage Store at -20°C
Molecular Weight (g/mol) Observed: 2404.64
Quantity 5 mg
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