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Invitrogen™ Angiopoietin 2 Recombinant Rabbit Monoclonal Antibody (5H8U4)
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Catalog No. PIMA535095
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PIMA535095 100 μL
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Catalog No. PIMA535095 Supplier Invitrogen™ Supplier No. MA535095
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: LTFPNSTEEI KAYCDMEAGG GGWTIIQRRE DGSVDFQRTW KEYKVGFGNP SGEYWLGNEF VSQLTNQQRY VLKIHLKDWE GNEAYSLYEH FYLSSEELNY R.

ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiopoietin 2
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 5H8U4
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ANGPT2
Gene Accession No. O15123, O35462, O35608
Gene Alias AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand
Gene Symbols ANGPT2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ANGPT2 (O15123).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11601, 285, 89805
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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