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Angiotensin I Monoclonal Antibody (BGN/KA/4H), Invitrogen™

Catalog No. MA182995
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200 μg
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Catalog No. Quantity
MA182995 200 μg
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Catalog No. MA182995 Supplier Thermo Scientific Supplier No. MA182995

Description

Mouse Monoclonal Antibody

This antibody does not react with angiotensin II, III, or angiotensinogen in ELISA. Mouse anti Human Angiotensin I, clone Ang E9, is specific for Angiotensin I and does not react with angiotensin II, III or angiotensinogen in ELISA.

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiotensin I
Applications ELISA, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone BGN/KA/4H
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with <0.1% sodium azide; pH 7.2
Gene AGT
Gene Accession No. P01019
Gene Alias AGT; alpha-1 antiproteinase, antitrypsin; Ang I; Ang II; Ang III; Ang IV; Angiotensin 1-10; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 1-9; Angiotensin 2-8; Angiotensin 3-8; Angiotensin I; angiotensin II; Angiotensin III; Angiotensin IV; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; Des-Asp[1]-angiotensin II; FLJ92595; FLJ97926; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
Gene Symbols AGT
Host Species Mouse
Immunogen HMW conjugate Synthetic peptide corresponding to amino acids 40-49 of the angiotensinogen precursor (Swiss-Prot entry P01019).
Purification Method Protein G
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 183
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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