Angiotensin I Monoclonal Antibody (BGN/KA/4H), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA182995

Catalog No. MA182995

Description

This antibody does not react with angiotensin II, III, or angiotensinogen in ELISA. Mouse anti Human Angiotensin I, clone Ang E9, is specific for Angiotensin I and does not react with angiotensin II, III or angiotensinogen in ELISA.

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Specifications

• Antigen: Angiotensin I
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with <0.1% sodium azide; pH 7.2
• Gene Accession No.: P01019
• Gene Symbols: AGT
• Immunogen: HMW conjugate Synthetic peptide corresponding to amino acids 40-49 of the angiotensinogen precursor (Swiss-Prot entry P01019).
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunocytochemistry, Western Blot
• Clone: BGN/KA/4H
• Conjugate: Unconjugated
• Gene: AGT
• Gene Alias: AGT; alpha-1 antiproteinase, antitrypsin; Ang I; Ang II; Ang III; Ang IV; Angiotensin 1-10; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 1-9; Angiotensin 2-8; Angiotensin 3-8; Angiotensin I; angiotensin II; Angiotensin III; Angiotensin IV; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; Des-Asp[1]-angiotensin II; FLJ92595; FLJ97926; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 183
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid