Apexbio Technology LLC Angiotensin II 250mg

Supplier:  Apexbio Technology LLC A1042250

Angiotensin II an endogenous octapeptide exerts potent vasoconstrictive effects through activation of angiotensin receptors on vascular smooth muscle cells This peptide stimulates contraction via binding G protein-coupled receptors triggering intracellular signaling cascades involving phospholipase C activation subsequent IP3-dependent calcium release and protein kinase C-mediated pathways Angiotensin II additionally promotes aldosterone secretion from adrenal cortical cells enhancing renal sodium and water reabsorption Experimentally angiotensin II is utilized extensively for investigating mechanisms of hypertension cardiovascular remodeling vascular smooth muscle cell hypertrophy and inflammatory responses in vascular injury models Reported IC50 values for receptor binding typically range between 1-10 nM depending on assay conditions

Catalog No. 50-000-63031