Angiotensin II/III Monoclonal Antibody (Ang II E7), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA182996

Catalog No. MA182996

Description

Predicted to react with horse, pig, rat and sheep based on sequence homology. Mouse anti Human angiotensinogen II antibody, clone 13/96/Ang E7 reacts with Angiotensin II and III.Negligible reactivity was observed with Angiotensin I or Angiotensinogen.

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Angiotensin III is formed after a terminal aspartic acid amino acid group is cleaved by aminopeptidase A. Angiotensin III has decreased effect on blood pressure, but maintains angiotensin II's hormonal effects. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Specifications

• Antigen: Angiotensin II/III
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with <0.1% sodium azide
• Gene Accession No.: P01019
• Gene Symbols: AGT
• Immunogen: Peptide sequence [DRVYIHPF] corresponding to angiotensin II, conjugated to a proprietary molecular weight carrier.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunocytochemistry, Western Blot
• Clone: Ang II E7
• Conjugate: Unconjugated
• Gene: AGT
• Gene Alias: AGT; alpha-1 antiproteinase, antitrypsin; Ang I; Ang II; Ang III; Ang IV; Angiotensin 1-10; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 1-9; Angiotensin 2; Angiotensin 2-8; Angiotensin 3-8; Angiotensin I; angiotensin II; Angiotensin III; Angiotensin IV; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; Des-Asp[1]-angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 183
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid