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Angiotensin II/III Monoclonal Antibody (Ang II E7), Invitrogen™

Catalog No. MA182996
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200 μg
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MA182996 200 μg
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Catalog No. MA182996 Supplier Thermo Scientific Supplier No. MA182996

Description

Mouse Monoclonal Antibody

Predicted to react with horse, pig, rat and sheep based on sequence homology. Mouse anti Human angiotensinogen II antibody, clone 13/96/Ang E7 reacts with Angiotensin II and III.Negligible reactivity was observed with Angiotensin I or Angiotensinogen.

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Angiotensin III is formed after a terminal aspartic acid amino acid group is cleaved by aminopeptidase A. Angiotensin III has decreased effect on blood pressure, but maintains angiotensin II's hormonal effects. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiotensin II/III
Applications ELISA, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone Ang II E7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with <0.1% sodium azide
Gene AGT
Gene Accession No. P01019
Gene Alias AGT; alpha-1 antiproteinase, antitrypsin; Ang I; Ang II; Ang III; Ang IV; Angiotensin 1-10; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 1-9; Angiotensin 2; Angiotensin 2-8; Angiotensin 3-8; Angiotensin I; angiotensin II; Angiotensin III; Angiotensin IV; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; Des-Asp[1]-angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; SERPINA8
Gene Symbols AGT
Host Species Mouse
Immunogen Peptide sequence [DRVYIHPF] corresponding to angiotensin II, conjugated to a proprietary molecular weight carrier.
Purification Method Protein G
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 183
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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