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ANKRD28 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550548

Catalog No. PA550548


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Description

Description

The antibody detects endogenous levels of total ANKRD28 protein.

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.
Specifications

Specifications

ANKRD28
Polyclonal
Unconjugated
ANKRD28
Liquid
ANKRD28
Synthetic peptide corresponding to residues near the C terminal of human Ankyrin repeat domain 28
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
2.1 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
O15084, Q505D1
KIAA0379
Rabbit
IgG
100 μL
-20°C
Primary
105522, 23243
Documents
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