Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ Anthrax Protective Antigen Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141128

Catalog No. 01-675-708


Only null left
Add to Cart

Description

Description

Suggested positive control: PA recombinant protein.

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Anthrax Protective Antigen
Polyclonal
Unconjugated
Anthrax PA
Synthetic peptide corresponding to residues 186-192 of Anthrax Pa.
RUO
Bacteria
Antibody
IgG
Western Blot
Conc. Not Determined
Whole serum, PBS with 0.05% BSA and 0.05% sodium azide
Rabbit
200 μL
Primary
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.