Invitrogen™ Anthrax Protective Antigen Polyclonal Antibody

Catalog No.	Quantity
01-675-708	200 μL

Catalog No. 01-675-708 Supplier Invitrogen™ Supplier No. PA141128

Description

Rabbit Polyclonal Antibody

Suggested positive control: PA recombinant protein.

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.

Specifications

• Antigen: Anthrax Protective Antigen
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Alias: Anthrax PA
• Host Species: Rabbit
• Immunogen: Synthetic peptides corresponding to amino acids 186-192 of the Anthrax PA protein (approx. 83 kDa).
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Bacteria
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG