Learn More
List Biological Laboratories Inc Anthrax Protective Antigen, Activated (PA 63) from B. anthracis, 0.5 mg

Supplier: List Biological Laboratories Inc 174

Since 1978, List Labs products are unsurpassed in quality, consistency, and reliability for the success of your research and development projects! Three proteins are collectively known as anthrax toxin: protective antigen (PA, 83 kDa), lethal factor (LF, 90 kDa) and edema factor (EF, 89 kDa). These proteins play a key role in the pathogenesis of anthrax. EF and LF have enzymatic functions associated with their carboxyl terminals, but require PA to achieve their biological effects. The amino terminal ends of EF and LF bind to PA and are responsible for translocation through the pore formed by the PA heptamer. Protease cleavage of PA is an essential step in exposing the binding sites for EF and LF. Cleavage also allows the formation of the heptamer. Pertactin is produced recombinantly in the native host and trypsin activated and purified, producing the active binding PA63.
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.