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Actin Ab-5 Mouse, Unlabeled, Clone: C4/ACTIN, BD

Mouse Monoclonal Antibody

$226.00 - $448.00

Specifications

Antigen Actin Ab-5
Isotype IgG1, κ
Immunogen Chicken gizzard muscle Actin
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612657
View Documents Promotion Details
BD Biosciences
612657
150μg
Each for $448.00
Add to cart
 
BDB612656
View Documents Promotion Details
BD Biosciences
612656
50μg
Each for $226.00
Add to cart
 
Description

Description

Changes in cellular morphology, adhesion, and motility occur through the reorganization of the actin cytoskeleton. This reorganization of actin filaments results from interactions between actin and actin-binding proteins. Actin is a 42kDa protein that is known as G-actin in its monomeric form. Polymerization of G-actin monomers leads to the generation of flexible filaments, 5-9 nm in diameter, called F-actin. F-actin may be organized in linear bundles called stress fibers or in two-dimensional networks. The latter are highly concentrated beneath the plasma membrane and form the actin cortex. Regulation of actin cytoskeletal dynamics occurs through actin-binding proteins. These proteins bind to G- and/or F-actin and regulate various aspects of actin cytoskeletal dynamics, such as polymerization and depolymerization of actin, cross-linking of actin filaments into bundles, interaction of actin-based structures with membranes and other cytoskeletal elements, and locomotion of actin-based structures. Thus, the actin cytoskeleton is a complex matrix consisting of G- and F-actin along with the multitude of interactions between these actin forms and a variety of different types of actin-binding proteins. The C4 monoclonal antibody reacts with all known isoforms of actin in vertebrate muscle and non-muscle cells.

Immunofluorescence, Western Blotting

Specifications

Specifications

Actin Ab-5
Chicken gizzard muscle Actin
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
C4/ACTIN
250μg/mL
SDS
Product Certifications

For Research Use Only.

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