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MilliporeSigma™ anti-Actin Clone: 2G2,

Catalog No. MABT826MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABT826MI 100 μL Unconjugated
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Catalog No. MABT826MI Supplier MilliporeSigma™ Supplier No. MABT826
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Description

Mouse Monoclonal Antibody

Specifically detects Actin Clone: 2G2 in Chicken, Frog, Human, Monkey, Mouse, Rabbit, Rat samples, and it is validated for Immunocytochemistry, Western Blotting

Actin, alpha skeletal muscle (UniProt P68135; also known as Alpha-actin-1) is encoded by the ACTA1 (also known as ACTA) gene (Gene ID 100009506) in Oryctolagus cuniculus (Rabbit) species. Actins exist in a variety of structural states, depending on the specific ionic conditions or the interaction with ligand proteins. The oligomeric and polymeric forms that actin molecules assume are dependent on the distinct conformations they adopt. Research indicates distinct actin conformations/structures in the nucleus and the cytoplasm of different cell types and that their distribution varies in response to external signals. In additon to serving as the basic building blocks of cytoskeletal microfilaments, actins are involved in multiple nuclear functions and adopt specific conformations that are important for their association with nuclear actin-binding proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Actin
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 2G2
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgMκ antibody in PBS with 0.05% sodium azide.
Gene Accession No. P68135
Gene Symbols ACTA1, ACTA
Host Species Mouse
Immunogen Reconstituted complex of rabbit skeletal muscle actin and calf thymus profilin.
Purification Method Purified by ion-exchange chromatography
Quantity 100 μL
Regulatory Status RUO
Research Discipline Cell Structure
Primary or Secondary Primary
Test Specificity Clone 2G2 recognizes a tripartite epitope identified in a region of the actin monomer (G-actin) that is not exposed on the surface the filamentous F-actin, but is accessible on the surface of profilin-complexed actin molecule (Gonsior, S.M., et al. (1999). J. Cell Sci. 112 (Pt 6):797-809).
Target Species Chicken, Frog, Human, Monkey, Mouse, Rabbit, Rat
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgM κ
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For Research Use Only

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