anti-AKT1 Matched Antibody Pair, Abnova

Supplier:  Abnova Corporation H00000207AP11

Catalog No. 89-017-206

Includes: Rabbit affinity purified polyclonal anti-AKT1 (100μg); Mouse monoclonal anti-AKT1, IgG2aκ (20μg); Sufficient for at least 3-5 x 96 well plates using recommended protocols.

Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.

Host Species: Rabbit; Mouse
Species Reactivity: Human

ELISA

Specifications

• Antigen: AKT1
• Classification: Monoclonal/Polyclonal
• Description: This antibody pair set comes with matched antibody pair to detect and quantify protein level of human AKT1.
• Gene Alias: AKT/MGC99656/PKB/PKB-ALPHA/PRKBA/RAC/RAC-ALPHA
• Host Species: Mouse, Rabbit
• Quantity: 1 Set
• Primary or Secondary: Primary
• Includes: Antibody pair set content: 1. Capture antibody: rabbit MaxPab™ affinity purified polyclonal anti-AKT1 (100 μg) 2. Detection antibody: mouse monoclonal anti-AKT1, IgG2a Kappa (20 μg) *Reagents are sufficient for at least 1-2 x 96 well plates using recommended protocols.
• Content And Storage: Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.

• Applications: ELISA
• Conjugate: Unconjugated
• Gene: AKT1
• Gene Symbols: AKT1
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 207
• Target Species: Human
• Isotype: IgG2a