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APOE Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527088

Catalog No. PIPA527088


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Description

Description

PA5-27088 targets Apo E in IHC (P), IP, IF, and WB applications and shows reactivity with Human samples. The PA5-27088 immunogen is synthetic peptide corresponding to a region within amino acids 255 and 317 of Human Apo E. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Chylomicron remts and very low density lipoprotein (VLDL) remts are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remts.
Specifications

Specifications

APOE
Polyclonal
Unconjugated
APOE
Liquid
APOE
Synthetic peptide corresponding to a region within amino acids 255 and 317 of Human Apo E
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.66 mg/mL
PBS with 20% glycerol and 0.025% Proclin 300; pH 7
P02649
AD2, LDLCQ5, LPG, apo-E, apolipoprotein E3
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
348
Documents
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