AVEN Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520287
Despite its predicted molecular weight, Aven often migrates at 55kDa in SDS-PAGE. A suggested positive control is Raji cell lysate. PA5-20287 can be used with blocking peptide PEP-0405.Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
|PBS with 0.02% sodium azide|
|PDCD12; cell death regulator Aven; programmed cell death 12|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|311299, 57099, 74268|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|A 14 amino acid peptide from near the carboxy terminus of human Aven.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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