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Bcl-2 Mouse, Unlabeled, Clone: 7, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610538

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Catalog No. BDB610538


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Description

Description

Human hematopoietic malignancies are often characterized by gene rearrangements which deregulate gene expression. The Bcl-2 gene (B-cell leukemia/lymphoma 2) was discovered by walking the chromosomal breakpoints t(14,18). This gene consists of two exons and several transcripts that encode two different protein products, Bcl-2α and Bcl-2β. Both are approximately 26-30kDa and differ at their C-terminal region. Bcl-2 suppresses programmed cell death (apoptosis) and this property appears to be modulated by homodimerization or association with Bax and Bad, two cell death promoters.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

Bcl-2
7
Unconjugated
Affinity Purified
Aqueous buffered solution containing BSA
50μg
Cell Biology
Primary
Canine, Chicken, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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