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Rat Anti-Blimp-1 Rat, PE, Clone: 6D3, BD

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BDB564702 50 μg
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Catalog No. BDB564702 Supplier BD Biosciences Supplier No. 564702
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Description

Rat Monoclonal Antibody

The 6D3 monoclonal antibody specifically binds to mouse B lymphocyte-induced maturation protein 1 (Blimp-1) and crossreacts with human BLIMP-1. Blimp-1 is a 98 kDa zinc finger-containing protein that is encoded by the Prdm1 gene. Blimp-1 was first discovered as a transcriptional repressor of the IFN- β promoter. Blimp-1 is critical for primordial germ cells specification in the early embryo and induction of terminal cell differentiation in multiple somatic cell types. It is largely known as a master regulator of antibody-secreting plasma cells due to its function in the repression of PAX5 , CIITA and cMYC genes. Blimp-1 also controls T cell homeostasis and effector differentiation through different mechanisms, including repression of IL-17 producing cells. Blimp-1 also plays roles in the maturation and activity of dendritic cells and natural killer cells.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Rat Anti-Blimp-1
Applications Flow Cytometry
Classification Monoclonal
Clone 6D3
Concentration 0.2mg/mL
Conjugate PE
Description BLIMP-1; PRDM1; PR domain containing 1, with ZNF domain; PRDI-BF1
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse Blimp-1 Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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