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BM28 Mouse, Unlabeled, Clone: 46, BD

Mouse Monoclonal Antibody

$286.00 - $568.50

Specifications

Antigen BM28
Clone 46
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610700
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BD Biosciences
610700
50 μg
Each for $286.00
Only null left
Add to Cart
 
BDB610701
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BD Biosciences
610701
150 μg
Each for $568.50
Only null left
Add to Cart
 
Description

Description

BM28 is a phosphoprotein that migrates at 125kDa in SDS PAGE with a hyperphosphorylated form migrating as a slightly slower band. The ratio of the phosphorylation states alters with the phases of cell cycle - in M, the “fast” phosphorylated BM28 is the major form found, while in G1 phase, the “slow”, hyperphosphorylated BM28 predominates. The cellular localization of BM28 is also cell cycle dependent. In G1, most of the BM28 is chromatin bound, whereas, by M phase, the BM28 is still nuclear, but not associated with the DNA. BM28 is necessary for both entry into S phase and cell division as determined by microinjection inhibition experiments. Microinjection of a BM28 antibody into synchronised cells in G1 phase inhibits DNA replication. When injected during S phase or later, no effect on DNA replication is seen, but cell division is inhibited.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

BM28
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
46
Western Blot
Unconjugated
RUO
Canine, Chicken, Human, Mouse, Rat
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Store undiluted at -20°C.
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