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BMX Mouse, Unlabeled, Clone: 40, BD

Catalog No. p-3851955 Shop All BD Biosciences Products
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BDB610792 50 μg
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Catalog No. BDB610792 Supplier BD Biosciences Supplier No. 610792
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Description

Mouse Monoclonal Antibody

BMX ( b one m arrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.

TRUSTED_SUSTAINABILITY

Specifications

Antigen BMX
Applications Western Blot
Classification Monoclonal
Clone 40
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human BMX aa. 138-276
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Chicken, Human, Mouse
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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