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Caspase-3/CPP32 Mouse anti-Mouse, Unlabeled, Clone: 46, BD

Mouse Monoclonal Antibody

$207.00 - $415.00

Specifications

Antigen Caspase-3/CPP32
Isotype IgG1
Immunogen Mouse CPP32 aa. 25-145
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611048
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BD Biosciences
611048
50μg Each for $207.00
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BDB611049
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BD Biosciences
611049
150μg Each for $415.00
Add to cart
 
Description

Description

Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic cells are characterized by loss of cell volume, plasma membrane blebbing, nuclear condensation, chromatin aggregation, and endonucleocytic degradation of DNA into nucleosomal fragments. Caspase-3 (CPP32, Yama, apopain) is a member of the family of cysteine proteases which includes interleukin-1beta-converting enzyme (ICE) and C. elegans protein, Ced-3. An apoptotic signal such as granzyme B of cytotoxic T-cells (CTLs) or ICE-like proteases induces the intracellular cleavage of Caspase-3 from the inactive proform (32kDa) to the active form which consists of the p20, p17, and p12 subunits. The active form of Caspase-3 cleaves several other apoptotic proteins including proteins such as DNA fragmentation factor (DFF). Apoptosis can be inhibited by coexpression of Bcl-2 as well as inhibitors of Caspase-3 or other members of the family of cysteine proteases. This antibody recognizes the mouse 32kDa pro-Caspase-3 and the p17 cleaved form of Caspase 3 in T cell lymphocytes treated with camptothecin.

Immunofluorescence, Western Blotting

Specifications

Specifications

Caspase-3/CPP32
Mouse CPP32 aa. 25-145
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
CPP32
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
46
250μg/mL
Store undiluted at -20°C.

For Research Use Only.

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