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MilliporeSigma™ anti-Cathepsin D Ab-2, Polyclonal

Catalog No. IM16100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
IM16100UG 100 μg Unconjugated
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Catalog No. IM16100UG Supplier MilliporeSigma™ Supplier No. IM16100UG

Description

Rabbit Polyclonal Antibody

Specifically detects Cathepsin D Clone: in Human samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immuno Blotting

Cathepsin D (CD) is a normal lysosomal proteinase expressed in all cells. It is an aspartyl proteinase, with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. CD is synthesized as an inactive 52kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid pro fragment and an internal cleavage to generate the two chain form made up of 34 and 14kDa subunits. It contains the mannose-6-phosphate lysosomal localization signal which targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, CD is abnormally processed and is secreted in its 52kDa precursor form. Numerous clinical studies as well asin vitro evidence suggest that CD plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cathepsin D
Applications Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unconjugated
Formulation In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Host Species Rabbit
Immunogen purified human liver cathepsin D
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽52kDa latent form D and the ∽34kDa subunit, but not the ∽14kDa subunit of cathepsin D in breast carcinoma tissue extracts.
Target Species Human
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG
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