anti-CCNE1 Matched Antibody Pair, Abnova

Supplier:  Abnova Corporation H00000898AP21

Catalog No. 89-017-241

Includes: Rabbit MaxPab™ affinity purified polyclonal anti-CCNE1 (100μg); Mouse polyclonal anti-CCNE1 (40μL); Sufficient for at least 3-5 x 96 well plates using recommended protocols.

Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

ELISA

Specifications

• Antigen: CCNE1
• Classification: Monoclonal/Polyclonal
• Description: This antibody pair set comes with matched antibody pair to detect and quantify protein level of human CCNE1.
• Gene Alias: CCNE
• Host Species: Mouse, Rabbit
• Quantity: 1 Set
• Research Discipline: Cell Cycle
• Gene ID (Entrez): 898
• Target Species: Human
• Form: Serum

• Applications: ELISA
• Conjugate: Unconjugated
• Gene: CCNE1
• Gene Symbols: CCNE1
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Includes: Antibody pair set content: 1. Capture antibody: rabbit MaxPab™ affinity purified polyclonal anti-CCNE1 (100 μg) 2. Detection antibody: mouse polyclonal anti-CCNE1 (40 ul) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
• Content And Storage: Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.