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CD105 Mouse anti-Human, Rat, Clone: MEM-226, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119231

Catalog No. 01-675-995


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Description

Description

CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Specifications

Specifications

CD105
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P17813
CD105, END, HHT1, ORW, ORW1, CD105 antigen, ENG
Mouse
IgG2a
100 μg
4° C, do not freeze
Primary
2022
Flow Cytometry, Immunoprecipitation, Western Blot
MEM-226
Unconjugated
ENG
Liquid
ENG
Recombit Vaccinia virus containing the human CD105 cDNA.
Protein A
RUO
Antibody
Monoclonal
Human, Rat
Documents
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