CD105 Mouse anti-Human, Rat, Clone: MEM-226, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119231
DescriptionCD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
|PBS with 15mM sodium azide; pH 7.4|
|CD105, END, HHT1, ORW, ORW1, CD105 antigen, ENG|
|4° C, do not freeze|
|Flow Cytometry, Immunoprecipitation, Western Blot|
|Recombit Vaccinia virus containing the human CD105 cDNA.|
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