CD11b/Mac-1 Mouse anti-Human, APC, Clone: ICRF44, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB561015	BD Biosciences 561015	25 Tests
BDB550019	BD Biosciences 550019	100 Tests

Description

Reacts with the 165kDa adhesion glycoprotein (Mac-1, integrin αM subunit) which associates with the 95kDa integrin β2 (CD18) to form the CD11b/CD18 complex. CD11b/Mac-1 is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and as a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). This antibody significantly inhibits PMN aggregation in response to fMLP. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Host Species: Mouse
Clone: ICRF44
Isotype: IgG1, κ
Cross Reactivity: Human

Flow Cytometry

Specifications

• Antigen: CD11b
• Applications: Flow Cytometry
• Conjugate: APC
• Regulatory Status: RUO
• Target Species: Human
• Immunogen: Human monocytes
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Clone: ICRF44
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Immunology
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Isotype: IgG1 κ
• Purification Method: Affinity Purified
• Description: MAC-1A; Mac-1; ITGAM; Integrin alpha M; CR3A; CR-3 alpha; Mo1; SLEB6

For Research Use Only.