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CD11b/Mac-1 Mouse anti-Human, V450, Clone: ICRF44, BD

Catalog No. p-3968634 Shop All BD Biosciences Products
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BDB560481 30 Tests
BDB560480 120 Tests
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Description

Mouse Monoclonal Antibody

The ICRF44 monoclonal antibody reacts with CD11b, the 165kDa adhesion glycoprotein that associates with the 95kDa integrin β2 (CD18) to form the CD11b/CD18 complex, also known as Mac-1 or CR3. CD11b is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and is a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fMLP. The antibody is conjugated to BD Horizon™ V450, which has been developed for use in multicolor flow cytometry experiments and is available exclusively from BD Biosciences. It is excited by the Violet laser Ex max of 406nm and has an Em Max at 450nm. Conjugates with BD Horizon™ V450 can be used in place of Pacific Blue™ conjugates.

Host Species: Mouse
Clone: ICRF44 (also known as 44)
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human monocytes

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD11b
Applications Flow Cytometry
Classification Monoclonal
Clone ICRF44
Conjugate Violet Fluor 450 (V450)
Description Mac-1α, integrin αM subunit, CR3 α chain
Formulation Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human monocytes
Purification Method Affinity Purified
Quantity 30 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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