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CD124 Mouse anti-Human, PE, Clone: HIL4R-M57, BD

Catalog No. BDB552178 Shop All BD Biosciences Products
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Catalog No. BDB552178 Supplier BD Biosciences Supplier No. 552178
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Description

Mouse Monoclonal Antibody

The hIL4R-M57 antibody specifically binds to the α subunit (IL-4R α ) of the human Interleukin-4 Receptor complex which is also known as CD124. The human IL-4R α , also known as B cell stimulatory factor 1 receptor (BSF-1 receptor), is a 140 kDa transmembrane glycoprotein that is expressed by B and T lymphocytes and a variety of other hematopoietic and non-hematopoietic cells and cell lines. The cell surface IL-4R α chain binds IL-4 with high affinity and associates with either the common γchain (IL-4R α / γα exists in soluble form in biological fluids. In contrast to mice, in humans no distinct mRNA coding for sIL-4R has been described, suggested that human sIL4-R is exclusively produced by proteolytic cleavage of the cell surface receptor. The serum levels of soluble IL-4R α appear to elevate in pathological situations such as allergy and parasitic infections. Depending on the ratios of IL-4 and sIL-4R α present in the local milieu, the sIL-4R α may augment or antagonize the activities of IL-4. The immunogen used to generate the hIL4R-M57 hybridoma was soluble human IL-4R.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD124
Applications Flow Cytometry
Classification Monoclonal
Clone HIL4R-M57
Conjugate PE
Description IL-4 Receptor α Chain, CD124
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Soluble Human IL-4 Receptor
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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