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CD140a Rat anti-Mouse, NA/LE, Unlabeled, Clone: APA5, BD

Catalog No. BDB562171 Shop All BD Biosciences Products
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BDB562171 0.5 mg
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Catalog No. BDB562171 Supplier BD Biosciences Supplier No. 562171
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Description

Rat Monoclonal Antibody

The APA5 antibody monoclonal antibody specifically binds to CD140a, the Platelet-Derived Growth Factor Receptor alpha chain (PDGFR-a, PDGFR-α). CD140a is a receptor tyrosine kinase that is widely expressed on cells of mesenchymal origin in the embryo and adult. CD140a is expressed on several other cell types during embryonic development, but not on hematopoietic cells. CD140a binds to PDGF A and B chains, in contrast to PDGFR-b (CD140b) that binds only to the PDGF B chain. Biologically active PDGF is a disulphide-linked dimer, forming the AA, AB, and BB isoforms. Ligand binding to the PDGF Receptor induces the formation of receptor dimers (aa, ab, or bb), autophosphorylation, and internalization. The APA5 antibody has been demonstrated to block binding ofPDGF-AA to PDGFR-a-expressing cells in vitroand to block some PDGF-mediated developmental events in vivo.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD140a
Applications Flow Cytometry
Classification Monoclonal
Clone APA5
Concentration 1.0mg/mL
Conjugate Unconjugated
Description Pdgfra; Pdgfr2; PDGF-R alpha; Platelet derived growth factor receptor alpha
Formulation No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Host Species Rat
Immunogen Mouse PDGF Receptor ? chain
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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