CD141 Mouse anti-Human, BB515, Clone: 1A4, BD

Catalog No.	Quantity
BDB565084	50 Tests

Catalog No. BDB565084 Supplier BD Biosciences Supplier No. 565084

Description

Mouse Monoclonal Antibody

The 1A4 monoclonal antibody specifically binds to a 75 kDa, a single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin. CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes. It is also found on megakaryocytes, dendritic cells, peripheral blood moncytes, and neutrophils, but not on lymphocytes. Reports indicate that CD141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway. Thrombin loses its procagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C.

The antibody was conjugated to BD Horizon BB515 which was developed exclusively by BD Biosciences. With an excitation max of 490nm and an emission max of 515nm, BD Horizon BB515 can be excited by the 488nm laser and detected in a standard FITC set (e.g. 530/30-nm filter). This dye provides a much brighter alternative to FITC with less spillover into the PE detector.

Specifications

• Antigen: CD141
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 1A4
• Conjugate: Brilliant Blue 515 (BB515)
• Description: Thrombomodulin; TM; THBD; THRM; AHUS6; Fetomodulin; BDCA-3
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide
• Host Species: Mouse
• Immunogen: Purified Human Thrombomodulin
• Purification Method: Affinity Purified
• Quantity: 50 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG1 κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov