CD274 Mouse anti-Human, APC, Clone: MIH1, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563741
The MIH1 monoclonal antibody specifically binds to CD274, also known as Programmed Death Ligand 1 (PD-L1) and B7 Homolog 1 (B7-H1). CD274/PD-L1 and CD273/PD-L2 are members of the B7 family within the Immunoglobulin superfamily. These type I transmembrane glycoproteins function as ligands for CD279, likewise known as the Programmed Death 1 (PD-1) receptor. CD274 is expressed on activated dendritic cells, macrophages and T cells. Studies show some overlapping functions of CD274 and CD273 and indicate an important role for CD279 and its ligands in regulating T and B cell responses. CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, keratinocytes, and carcinomas. The MIH1 antibody is reportedly a blocking antibody.
|B7-H1; Programmed death ligand 1; PD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1|
|Human B7-H1 Transfected Cell Line|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
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