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CD28 Mouse anti-Human, PE-CF594, Clone: CD28.2, BD

Mouse Monoclonal Antibody

$198.80 - $420.00

Specifications

Antigen CD28
Clone CD28.2
Applications Flow Cytometry
Classification Monoclonal
Conjugate PE-CF594
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB562323
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BD Biosciences
562323
25 Tests
Each for $198.80
Only null left
Add to Cart
 
BDB562296
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BD Biosciences
562296
100 Tests
Each for $420.00
Only null left
Add to Cart
 
Description

Description

The CD28.2 monoclonal antibody specifically binds to CD28, a 44 kDa homodimeric transmembrane glycoprotein present on most mature T cells, thymocytes and plasma cells. CD28 is a costimulatory receptor that binds CD80 and CD86 as ligands and plays a very important role in T cell-B cell interactions. It has been suggested that CD28 initiates and regulates a separate and distinct signal transduction pathway from those stimulated by the TCR complex. Additionally, it has been reported that CD28 antibody clones vary in their ability to stimulate T cells to produce IL-2 and increase intracellular Ca2+ concentration. This finding suggests the existence of functionally distinct subregions on the CD28 molecule. CD28.2 has been demonstrated to bind to the same molecule as clone L293, another CD28 mAb, and has been reported to induce Ca2+ influx in Jurkat T cells.

This antibody is conjugated to BD Horizon PE-CF594, which has been developed exclusively by BD Biosciences as a better alternative to PE-Texas Red™. PE-CF594 excites and emits at similar wavelengths to PE-Texas Red™ yet exhibits improved brightness and spectral characteristics. Due to PE having maximal absorption peaks at 496nm and 564nm, PE-CF594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as PE-Texas Red™ (eg, 610/20-nm filter).

Specifications

Specifications

CD28
Flow Cytometry
PE-CF594
RUO
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
CD28 antigen; T44; Tp44; TP44
CD28.2
Monoclonal
Mouse
Human
DC28.1.3.3 hybridoma cells
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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