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CD31 Mouse anti-Human, Clone: MEM-05, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119199

Catalog No. 01-675-963


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Description

Description

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Specifications

Specifications

CD31
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P16284
CD31 antigen, CD31/EndoCAM, GPIIA′, PECA1, PECAM-1, CD31/EndoCAM, adhesion molecule, endoCAM, platelet endothelial cell adhesion molecule
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
5175
Flow Cytometry, Western Blot
MEM-05
Unconjugated
PECAM1
Liquid
PECAM1
Leucocytes from a patient suffering from a LGL type leukaemia.
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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